• Home
  • Contact us
  • About us
  • Our Product
    • Weight loss & Metabolic
    • Healing & Recovery
    • Hormone & Growth
    • Anti-Aging & Longevity
    • Cognitive & Neuro
    • Skin & Aesthetic
    • Limitless
    • Accessories
  • COAs
Search
Login / Register
Wishlist
1 item / $264.99
Menu
1 item $264.99
“Gastro Inflammation Research Formula (60 Capsules)” has been added to your cart. View cart
Click to enlarge
Home Limitless Pancragen Peptide (Lys-Glu-Asp-Trp) 20mg
P21 Peptide Spray
P21 Peptide Spray $176.49 – $328.29Price range: $176.49 through $328.29
Back to products
PE-22-28 Spray
PE-22-28 Spray $42.99 – $57.49Price range: $42.99 through $57.49

Pancragen Peptide (Lys-Glu-Asp-Trp) 20mg

$62.00

Compare
Add to wishlist
Category: Limitless Tags: Pancragen, Pancragen Peptide, Pancragen Peptide (Lys-Glu-Asp-Trp) 20mg, Pancragen Peptide 20mg, what is Pancragen Peptide
Share:
  • Description
  • Research
  • Reviews (0)
  • Shipping & Delivery
Description

Pancragen Peptide Description

Pancragen is a tetrapeptide bioregulator composed of the amino acid sequence Lys-Glu-Asp-Trp (KEDW). This laboratory-grade peptide demonstrates significant biological activity in experimental settings, particularly in pancreatic cell culture studies.

Research indicates that Pancragen exhibits notable effects on pancreatic function and glucose metabolism at nanomolar concentrations. The pancreas peptide has been shown to help normalize insulin production and improve pancreatic beta cell regeneration in experimental models, suggesting potential applications in metabolic research.

Pancragen’s mechanism of action appears to involve modulation of gene expression in pancreatic tissues, potentially activating regenerative pathways that support cellular rejuvenation. The peptide demonstrates tissue-specific affinity with minimal off-target effects in laboratory investigations.

This specialized bioregulator represents a valuable research tool for laboratories studying pancreatic function, insulin signaling pathways, and age-related changes in glucose metabolism. Pancragen offers researchers a well-characterized compound for investigating pancreatic cellular resilience and metabolic regulation.

Peptide Specifications

  • Sequence: Lys-Glu-Asp-Trp (KEDW)
  • Molecular Formula: C₂₆H₃₆N₆O₉
  • Molecular Weight: 576.25 g/mol
  • PubChem CID: 68452887
  • Synonyms: SCHEMBL5491754
  • IUPAC Name: (4S)-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-2,6-diaminohexanoyl]amino]-5-oxopentanoic acid
  • Storage: Store in lyophilized form at or below -20°C

Research Applications

  • Pancreatic Endocrine Function
  • Glucose Metabolism
  • Geroprotection and Tissue Aging
  • Diabetes Research

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

Research

Research

Pancragen has been studied for its potential to restore function of the pancreas in the context of aging and type 2 diabetes. Research has focused on its effects in animal models, examining both endocrine regulation and cellular differentiation in the pancreas.

Mechanisms of Action

In human embryonic pancreatic cell cultures, pancragen specifically stimulated the expression of differentiation factors (CXCL12, Hoxa3), especially in aged cells. This tissue-specific stimulation was more pronounced in older cultures, indicating a possible geroprotective mechanism.[1]

Effects on Pancreatic Endocrine Function

In older animals, pancragen administration led to decreased basal insulin and C-peptide levels, increased glucose disappearance rates, and normalization of glucose, insulin, and C-peptide responses after glucose administration. These effects partially persisted for three weeks after stopping treatment.[2]

Pancragen was effective in restoring age-related endocrine dysfunctions of the pancreas, suggesting its promise as a therapeutic agent for age-associated glucose intolerance and type 2 diabetes.[2]

Effectiveness in Diabetes Models

In elderly patients with type 2 diabetes, pancragen administration led to significant reductions in fasting glucose, improved glucose tolerance, and decreased insulin resistance. These benefits were not observed in patients who did not receive pancragen, suggesting a specific therapeutic effect.[3] 

In diabetic rats, pancragen normalized the adhesion of mesenteric capillary endothelium, suggesting protective effects on vascular function during early diabetes, though it did not affect capillary permeability.[4] 

Oral pancragen produced a significant hypoglycemic effect during treatment, supporting its potential for blood glucose regulation in diabetes. The peptide also demonstrated homeostatic effects in diabetic conditions, further supporting its research potential.[4]

References

  1. Khavinson, V., Linkova, N., Polyakova, V., Kheifets, O., Tarnovskaya, S., & Kvetnoy, I. (2012). Peptides Tissue-Specifically Stimulate Cell Differentiation during Their Aging. Bulletin of Experimental Biology and Medicine, 153, 148-151. https://doi.org/10.1007/s10517-012-1664-1.
  2. Goncharova, N., Ivanova, L., Oganian, T., Vengerin, A., & Khavinson, V. (2014). [Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys].. Advances in gerontology = Uspekhi gerontologii, 27 4, 662-7.
  3. Korkushko, O., Khavinson, V., Shatilo, V., Antonyk-Sheglova, I., & Bondarenko, E. (2011). Prospects of Using Pancragen for Correction of Metabolic Disorders in Elderly People. Bulletin of Experimental Biology and Medicine, 151, 454-456. https://doi.org/10.1007/s10517-011-1354-4.
  4. Khavinson, V., Gavrisheva, N., Malinin, V., Chefu, S., & Trofimov, E. (2007). Effect of pancragen on blood glucose level, capillary permeability and adhesion in rats with experimental diabetes mellitus. Bulletin of Experimental Biology and Medicine, 144, 559-562. https://doi.org/10.1007/s10517-007-0377-3.
Reviews (0)

Reviews

There are no reviews yet.

Be the first to review “Pancragen Peptide (Lys-Glu-Asp-Trp) 20mg” Cancel reply

Your email address will not be published. Required fields are marked *

Shipping & Delivery

Related products

Compare

5-Amino-1MQ Powder 9g

Limitless
$152.29 – $357.99Price range: $152.29 through $357.99
Product Description 5-amino-1MQ is a small molecule inhibitor that targets the enzyme nicotinamide n-methyltransferase (NNMT) for laboratory research applications. This
Add to wishlist
Select options
Quick view
Compare

Anti Wrinkle Research Formula 2oz

Limitless
$93.79
Indications FOR ALL SKIN TYPES: Photo-Aged, Dehydrated, Acne, Traumatized, Wounded Skin. Fine lines, wrinkles, dark circles, and puffiness under the
Add to wishlist
Add to cart
Quick view
Compare

Cagrilintide Tre 5mg

Weight loss & Metabolic, Limitless
$100.99 – $101.99Price range: $100.99 through $101.99
Product Description Cagrilintide is a synthetic long-acting amylin analogue designed for in vitro research applications. This modified protein targets both
Add to wishlist
Select options
Quick view
Compare

CardioCytogen 20mg

Limitless
$59.99
CardioCytogen Information Molecular formula: C18H31N7O9 Molecular weight: 489.5 g/mol PubChem CID: 156613454 Synonyms  SCHEMBL3194515 Research Applications: Cancer Research Prostate Health
Add to wishlist
Add to cart
Quick view
Compare

DSIP Spray 5mg

Anti-Aging & Longevity, Limitless
$44.99 – $57.99Price range: $44.99 through $57.99
Delta sleep-inducing peptide (DSIP) spray designed for in vitro research applications studying sleep patterns and circadian receptor mechanisms. DSIP Spray
Add to wishlist
Select options
Quick view
Compare

GHK-Cu 100mg (Copper Peptide)

Skin & Aesthetic, Limitless
$82.99 – $86.99Price range: $82.99 through $86.99
GHK-Cu Product Description GHK-Cu peptide is a naturally occurring copper tripeptide complex first isolated from human plasma in 1973. This
Add to wishlist
Select options
Quick view
Compare

GHK-Cu 2mg (60 Capsules)

Skin & Aesthetic, Limitless
$144.99
Research GHK-Cu Capsules Product Information Molecular formula: C16H28CuN6O6-2 Molecular weight: 463.98 g/mol PubChem CID: 156588903 Research Applications: Antioxidant and Anti-inflammatory Properties
Add to wishlist
Add to cart
Quick view
Compare

GHK-Cu Spray

Skin & Aesthetic, Limitless
$86.99 – $144.99Price range: $86.99 through $144.99
Great sources for reading  https://www.hindawi.com/journals/bmri/2015/648108/ https://www.hindawi.com/journals/bmri/2014/151479/. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/ http://www.skinbiology.com/Articles/AntiAgingActivityofGHK_JARCPFinal.pdf https://www.semanticscholar.org/paper/GHK-–-Copper-Peptide-in-Skin-Remodeling-and-!-in-Pickart/56992fa05930e1f6a22c3d84f80ff8ac6774f72b?p2df https://pubmed.ncbi.nlm.nih.gov/28370978/ https://www.walshmedicalmedia.com/open-access/effects-of-ghkcu-on-mmp-and-timp-expression-collagen-and-elastin-production-and-facial-wrinkle-parameters-2329-8847-1000166.pdf https://pubmed.ncbi.nlm.nih.gov/27517151/ https://www.mdpi.com/2079-9284/2/3/236/htm https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556990/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508379/ Lyophilized Peptides: These peptides are freeze-dried,
Add to wishlist
Select options
Quick view

    At Mile High Limitless, we are committed to advancing scientific research by providing top-quality, USA-made research peptides.

    • 5555 N. Lamar Blvd, Austin, TX
    • Phone: +1 313 (208) 10-15
    Products
    • Bromantane Powder 10g Bromantane Powder 10g $39.89 – $140.19Price range: $39.89 through $140.19
    • GHK-Cu 100mg (Copper Peptide) GHK-Cu 100mg (Copper Peptide) $82.99 – $86.99Price range: $82.99 through $86.99
    • Methylene Blue Methylene Blue $139.99
    Our stores
    • Home
    • Contact us
    • About us
    • Our Product
      • Weight loss & Metabolic
      • Healing & Recovery
      • Hormone & Growth
      • Anti-Aging & Longevity
      • Cognitive & Neuro
      • Skin & Aesthetic
      • Limitless
      • Accessories
    • COAs
    All rights reserved @ milehighlimitless.com
    • Menu
    • Categories
    • Accessories
    • Home
    • Contact us
    • About us
    • Our Product
      • Weight loss & Metabolic
      • Healing & Recovery
      • Hormone & Growth
      • Anti-Aging & Longevity
      • Cognitive & Neuro
      • Skin & Aesthetic
      • Limitless
      • Accessories
    • COAs
    • Wishlist
    • Compare
    • Login / Register
    Shopping cart
    Close
    Sign in
    Close

    Lost your password?

    No account yet?

    Create an Account
    Start typing to see products you are looking for.
    Shop
    Wishlist
    1 item Cart
    My account