GHK-Cu Spray

GHK-Cu Fact Sheet

GHK-Cu (Copper Peptide) Overview

GHK-Cu, also known as copper peptide GHK-Cu, is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. It was first isolated from human plasma and has since been found in other areas of the body, such as saliva and urine. Copper peptides are naturally occurring protein fragments that have a strong attraction to copper ions and are thought to play a vital role in the normal functioning of the body. GHK-Cu has been the subject of numerous studies, which have revealed several roles and benefits in the human body.

GHK-Cu and Wound Healing

GHK-Cu has been shown to improve the healing of ischemic open wounds in rats, leading to faster healing. It stimulates the synthesis of collagen, elastin, and glycosaminoglycans in the skin, which are essential for wound healing. In the same study, wounds treated with GHK-Cu showed a decreased concentration of metalloproteinases 2 and 9, which are enzymes involved in the breakdown of extracellular matrix during the wound healing process [R].

GHK-Cu stimulates collagen and decorin production, which are essential for tissue regeneration and wound healing. It also increases cellular stemness and secretion of trophic factors by mesenchymal stem cells. GHK-Cu also promotes skin remodeling, which is crucial for wound healing and regeneration [R].

GHK-Cu Antioxidant and Anti-Inflammatory Effects

GHK-Cu (glycyl-l-histidyl-l-lysine copper) has been shown to have antioxidant and anti-inflammatory effects in various studies. GHK-Cu may prevent oxidative stress in the skin by regulating copper levels and influencing the activity of various antioxidant genes [R].

GHK-Cu has also been shown to ameliorate lipopolysaccharide-induced acute lung injury in mice by suppressing inflammation and reducing oxidative damage [R].

GHK-Cu and Skin Remodeling and Regeneration

GHK-Cu has been shown to improve the appearance of aging skin in clinical studies. Both GHK and GHK-Cu have been found to have anti-inflammatory and tissue remodeling properties [R]. 

GHK-Cu and Promotion of Blood Vessel Growth

GHK-Cu and Hair Growth

GHK-Cu has been found to increase hair growth and thickness, as well as enlarge hair follicle size. GHK-Cu stimulates collagen synthesis by fibroblasts, which is necessary for hair growth and thickness [R].

GHK-Cu promotes the growth of human hair follicles by stimulating the proliferation and precluding the apoptosis of dermal papilla cells (DPCs). GHK-Cu has strong inhibitory effects on dihydrotestosterone (DHT), which is a key factor in hair loss regulation [R].

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