Thymalin Product Description

Thymalin is a synthetic version of thymulin, designed specifically for immune system research applications. This nine amino acid peptide maintains ≥98.5% purity through rigorous pharmaceutical-grade manufacturing processes. Each batch undergoes independent third-party testing to verify composition and quality standards.

Manufactured in USA facilities under Good Manufacturing Practices, Thymalin supports diverse laboratory investigations into cellular immunity, T-cell differentiation, and immune function mechanisms. Supplied as white lyophilized powder for reliable reconstitution. Research use only.

Peptide Specifications

SPECIFICATION	DESCRIPTION
Sequence	H-Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
Molecular Formula	C33H54N12O15
Molecular Weight	858.864 g/mol
CAS Number	63958-90-7
PubChem CID	3085284
Synonyms	Thymulin, Thymic Factor, Nonathymuli, Facteur Thymique Serique, Serum Thymic Factor
Purity	≥99% (HPLC)
Solubility	Soluble in BAC water
Storage Conditions	Store at ≤4°C, tightly sealed, away from heat and moisture
Physical Appearance	White lyophilized powder
Shelf Life	36 months from date of manufacture when stored properly
Quality Verification	Third-party tested by certified laboratory
Manufacturing Standard	USA-made, pharmaceutical-grade, GMP compliant
Intended Application	In vitro research applications only

Our Product Quality Guarantee

Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.

Buy Thymalin From Limitless Biotech

Limitless Biotech provides USA-manufactured Thymalin with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.

Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

Understanding Our Product Grades

We offer three distinct product grades to support varying research needs. Our Premium Lyophilized line is triple-tested for purity, endotoxins, and sterility, and in most cases includes both double third-party testing and manufacturer HPLC verification. The Standard Lyophilized grade is third-party purity tested and manufacturer verified. Our Standard (Non-Lyophilized) products are also manufacturer verified and third-party purity tested. All products meet a minimum purity of 98.5%, with the vast majority exceeding 99%. Each designation reflects a specific level of quality control and preparation.

Research

Thymalin is a peptide derived from the thymus gland, widely studied for its immunomodulatory and geroprotective effects. Research spans from its molecular mechanisms to applications in immune dysfunction, aging, and adjunctive therapy for various diseases.

Thymalin and Immune System Research

Thymalin promotes the differentiation of hematopoietic stem cells into mature T lymphocytes, increasing CD28 and decreasing CD44 and CD117. Research indicates enhanced immune cell maturation mechanisms, particularly relevant in COVID-19 studies where T cell suppression has been observed[1].

The KE and EW dipeptides in Thymalin modulate gene expression and protein synthesis related to cytokine storm in COVID-19. These peptides reduce pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) in immune cells, potentially downregulating excessive inflammation[2].

Research studies combining Thymalin with standard COVID-19 protocols demonstrate slowed decline of protective IgG antibodies and maintained adaptive immunity. Laboratory analysis shows normalized immune cell counts (CD4+, CD8+, NK cells) in severe cases, supporting immune status recovery[3].

Thymalin has shown research applications in acute respiratory syndrome, chronic bronchitis, trauma studies, and cancer research models, particularly in cellular immunity investigations[1][4][5].

Thymalin Research in Aging and Life Extension

Peptides derived from the thymus (such as Thymalin) and pineal gland (such as Epithalamin/Epitalon) have been studied for their potential to slow aging and extend lifespan.

Research studies demonstrate that Thymalin and Epithalamin normalize immune, endocrine, cardiovascular, and nervous system functions, supporting homeostasis and metabolism in elderly research subjects[6].

These peptides may act by activating transcription of proteins involved in tissue repair and immune function, especially in the thymus[7]. Both peptides show antioxidant properties and reduce tumor incidence in animal models[7][8].

The thymus and pineal gland interact through shared regulatory pathways, influencing immune, endocrine, and nervous system health. Their co-involution is linked to aging, and their hormones (including melatonin) play roles in longevity and disease prevention[9].

Cancer Research

Thymalin and related thymic peptides (such as thymosin alpha-1) stimulate T-cell-mediated immunity, increasing lymphoproliferative activity and enhancing both innate and adaptive immune responses. Research demonstrates enhanced anti-tumor immunity mechanisms and potential effects on tumor growth and progression in laboratory models[10].

In animal studies, Thymalin at low doses led to tumor growth arrest or regression, likely due to its effects on the thymus and immune system activation[11].

Clinical research studies have examined Thymalin as part of complex research protocols in cancer models, demonstrating pronounced immunomodulating effects and providing data on immunocorrection mechanisms when T-cell immunity is monitored[12].

Atherosclerosis Research

Research studies show Thymalin normalizes lymphocyte function, specifically restoring T-suppressor activity and improving immune cell sensitivity in animal models with high cholesterol, which may counteract immune dysfunction observed in atherosclerosis research[13].

Laboratory investigations demonstrate Thymalin’s hypolipidemic effects, showing reduced blood lipid levels in research models, a mechanism relevant to atherosclerosis studies[13].

References

Khavinson, V., Linkova, N., Kvetnoy, I., Polyakova, V., Drobintseva, A., Kvetnaia, T., & Ivko, O. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. Bulletin of Experimental Biology and Medicine. 2020; 170. https://doi.org/10.1007/s10517-020-05016-z.
Linkova, N., Khavinson, V., Diatlova, A., Petukhov, M., Vladimirova, E., Sukhareva, M., & Ilina, A. The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19. International Journal of Molecular Sciences. 2023; 24. https://doi.org/10.3390/ijms241713377.
Khavinson, V., Kuznik, B., Volchkov, V., Rukavishnikova, S., Titova, O., Akhmedov, T., Trofimova, S., Ryzhak, G., Potyomkin, V., & Saginbaev, U. Effect of thymalin on adaptive immunity in complex therapy for patients with COVID-19. . 2021; 98. https://doi.org/10.30629/0023-2149-2020-98-8-593-599.
Scientific, R., & Tillyashaikhov, M. STUDYING THE INDICATORS OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH OVARY CANCER AGAINST THE BACKGROUND IMMUNOPHARMACOTHERAPY. Problems of modern science and education. 2019 https://doi.org/10.20861/2304-2338-2019-134-002.
Dovnar, T., Mikhailova, N., & Khavinson, V. [Effect of thymalin on immunologic reactivity of patients with non-specific lung diseases].. Terapevticheskii arkhiv. 1989; 61 3.
Khavinson, V., & Morozov, V. Peptides of pineal gland and thymus prolong human life.. Neuro endocrinology letters. 2003; 24 3-4.
Khavinson, V. Peptides and Ageing.. Neuro endocrinology letters. 2002; 23 Suppl 3.
Anisimov, V., Khavinson, V., & Vg, M. Twenty Years of Study on Effects of Pineal Peptide Preparation: Epithalamin in Experimental Gerontology and Oncology. Annals of the New York Academy of Sciences. 1994; 719. https://doi.org/10.1111/j.1749-6632.1994.tb56853.x.
Rezzani, R., Franco, C., Hardeland, R., & Rodella, L. Thymus-Pineal Gland Axis: Revisiting Its Role in Human Life and Ageing. International Journal of Molecular Sciences. 2020; 21. https://doi.org/10.3390/ijms21228806.
Savino, W., & Lepletier, A. Thymus-derived hormonal and cellular control of cancer. Frontiers in Endocrinology. 2023; 14. https://doi.org/10.3389/fendo.2023.1168186.
Zhukova, G., Schikhlyarova, A., Barteneva, T., Shevchenko, A., & Zakharyuta, F. Effect of Thymalin on the Tumor and Thymus under Conditions of Activation Therapy In Vivo. Bulletin of Experimental Biology and Medicine. 2018; 165. https://doi.org/10.1007/s10517-018-4104-z.
Ev, B., IaV, B., VKh, K., & Vg, M. Use of thymalin in the complex treatment of patients with cancer of the uterus. . 1985
Ryzhenkov, V., Ogurtsov, R., Trubacheva, V., Popov, V., & Puzyreva, V. [Effect of thymalin on the development of experimental hyperlipidemia and atherosclerosis].. Voprosy meditsinskoi khimii. 1988; 34 1.