This product ships with a cold pack to ensure viability. Even if the cold pack is melted upon arrival, which is typical, the product will still be viable. For those in hotter climates, or are worried, it might be a good idea to suggest purchasing shipping insurance for added security.
| Container | 15ml Dropper Bottle |
|---|---|
| Presentation | Liquid |
What is Spermidine?
Spermidine is a naturally occuring polyamine compound that is found in ribosomes and living tissues. It has various metabolic functions within organisms and was originally isolated from semen. Spermidine helps regulate biological processes like calcium and sodium ion homeostasis, cell growth and proliferation, and cell death. It also plays a role in DNA and RNA regulation and stability. Additionally, spermidine acts as an antioxidant and anti-inflammatory agent. Spermidine is synthesized from the amino acid ornithine and is a precursor for other polyamines like spermine.
Spermidine and Longevity
Spermidine has been the subject of numerous studies due to its potential role in promoting longevity. The compound is found in foods like aged cheese and whole grains and has been linked to lifespan extension in various organisms, including yeast, flies, worms, and mammals.
A 2023 study found that nutritional supplementation with spermidine could reduce age-related pathology and increase lifespan in several organisms, including humans. This research suggested that spermidine might play a role in cell homeostasis, with increased levels of polyamine synthesizing enzymes associated with cell proliferation [R].
Another study from the same year found that a long-term, high polyamine diet, which increases spermine (a polyamine closely related to spermidine), could suppress aberrant gene methylation and inflammation that progress with age. These conditions are strongly associated with the development of several age-related diseases and senescence [R].
In 2020, research showed that spermidine could promote autophagy in cardiac muscle, a vital process for the recycling of dysfunctional and potentially harmful cellular components. This process could prevent interruptions in the homeostatic environment and prevent disease, making spermidine a promising candidate for further research into treatments for age-related cardiac decline [R].
Finally, a 2024 review highlighted the potential of plant-derived compounds, including spermidine, as pro-longevity agents [R].
Spermidine and Autophagy
Spermidine has been studied for its potential to induce autophagy, a cellular process that recycles and removes unnecessary or dysfunctional components. This process is important for maintaining cellular health and function, and its enhancement has been linked to a broad range of health benefits.
In a 2023 study, researchers found that exogenous spermidine could induce autophagy and reduce oxidative stress in the ovaries and granulosa cells of Sichuan white geese. This study showed that spermidine could increase the levels of autophagy-associated proteins, thereby reducing the accumulation of reactive oxygen species and the rate of apoptosis [R].
Another study from 2023 found that a supplement combining spermidine and eugenol, a compound found in clove oil, could stimulate autophagy in human intestinal cells. The supplement was found to reduce inflammation and increase autophagy, suggesting potential benefits for intestinal health [R].
In 2022, a study linked many of the cellular effects of spermidine to autophagy. The researchers suggested that enhancing autophagy could be a strategy for protecting against age-related diseases [R].
A 2019 study found that spermidine could protect against liver injury caused by ischemia-reperfusion, a condition that occurs when blood supply returns to tissue after a period of ischemia or lack of oxygen. The researchers found that spermidine regulated autophagy through the AMPK-mTOR-ULK1 signaling pathway, suggesting potential benefits for liver health [R].
In 2020, a study highlighted spermidine’s role in promoting autophagy in cardiac muscle, which could help prevent cardiac dysfunction. The researchers suggested that spermidine could be a promising candidate for further research into treatments for age-related cardiac decline [R].
Legal Disclaimer
This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.
Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.
The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.
Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.
Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.
Understanding Our Product Grades
We offer three distinct product grades to support varying research needs. Our Premium Lyophilized line is triple-tested for purity, endotoxins, and sterility, and in most cases includes both double third-party testing and manufacturer HPLC verification. The Standard Lyophilized grade is third-party purity tested and manufacturer verified. Our Standard (Non-Lyophilized) products are also manufacturer verified and third-party purity tested. All products meet a minimum purity of 98.5%, with the vast majority exceeding 99%. Each designation reflects a specific level of quality control and preparation.
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