Name: Selank (N-Acetyl Selank)
SKU: 16435
Availability: InStock

Description

Selank Product Description

Selank is a synthetic heptapeptide composed of 7 amino acids with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro, developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. This peptide demonstrates remarkable stability and exhibits anxiolytic, nootropic, and immunomodulatory effects throughout various biological systems.

Mechanistically, Selank appears to modulate the GABAergic neurotransmitter system through allosteric modulation of GABA receptors, influence monoamine neurotransmitter concentrations, and affect the expression of brain-derived neurotrophic factor (BDNF). The peptide also modulates cytokine expression and enhances metabolic stability compared to its natural predecessor tuftsin.

Peptide Specifications

Property	Information
Chemical Formula	C₃₃H₅₇N₁₁O₉
CAS Number	129954-34-3
PubChem CID	11765600
Molecular Weight	751.887 g/mol
Chemical Name	L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolylglycyl-L-proline
Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
Alternate Name(s)	Selanc, TP-7, Tuftsin analog, Heptapeptide Selank, UNII-TS9JR8EP1G
Primary Research Areas	Anxiolytic and stress response modulation Cognitive enhancement and memory formation Neuroprotective mechanisms GABAergic system modulation Immunomodulatory effects Brain-derived neurotrophic factor (BDNF) expression Monoamine neurotransmitter regulation

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Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.

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Limitless Biotech provides USA-manufactured Selank peptide with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.

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This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

Understanding Our Product Grades

We offer three distinct product grades to support varying research needs. Our Premium Lyophilized line is triple-tested for purity, endotoxins, and sterility, and in most cases includes both double third-party testing and manufacturer HPLC verification. The Standard Lyophilized grade is third-party purity tested and manufacturer verified. Our Standard (Non-Lyophilized) products are also manufacturer verified and third-party purity tested. All products meet a minimum purity of 98.5%, with the vast majority exceeding 99%. Each designation reflects a specific level of quality control and preparation.

Selank Research

Selank is a synthetic peptide developed as an anxiolytic and nootropic agent, with effects similar to classical benzodiazepines but a distinct molecular profile. Research has explored its mechanisms of action, physiological effects, and potential applications in stress, anxiety, and cognitive impairment.

Selank and GABAergic System Modulation

Selank acts as a positive allosteric modulator of GABA receptors, enhancing [3H]GABA binding in a concentration-dependent and subtype-selective manner[1]. It increases the number of specific GABA binding sites on neuronal membranes without altering receptor affinity, indicating both direct receptor modulation and initiation of broader cellular regulatory mechanisms[2].

In animal models, Selank administration leads to significant changes in the expression of genes involved in GABAergic neurotransmission, with effects observed as early as one hour post-administration. These changes are similar to those seen with GABA itself, supporting a shared mechanism of action[3].

In neuroblastoma cell cultures, Selank alone did not alter mRNA levels of GABAergic genes. However, when combined with GABA, Selank suppressed GABA-induced gene expression changes, and when combined with olanzapine, it enhanced gene expression alterations compared to olanzapine alone[4].

Anxiolytic Effects

Selank demonstrates pronounced anxiolytic effects in studies, often matching the effectiveness of benzodiazepines like diazepam and phenazepam in reducing anxiety symptoms[5].

Clinical research shows Selank provided significant anxiety reduction and mild cognitive benefits, with effects lasting up to a week and a positive impact on quality of life[5].

In animal models, Selank alone was most effective at reducing anxiety induced by stressors, while its combination with diazepam was especially effective under chronic stress conditions[6].

Cognitive and Neuroprotective Effects

Selank improves cognitive performance, including memory and learning, in animal models. It prevents memory and attention deficits caused by chronic alcohol exposure and restores cognitive processes impaired by early-life catecholaminergic system damage[7].

Selank also prevents ethanol-induced increases in BDNF levels in the hippocampus and prefrontal cortex, indicating that its cognitive function and neuroprotective effects are linked to the regulation of BDNF, a key neurotrophin involved in neuronal survival and plasticity[7].

Immunomodulatory and Antiviral Properties

Selank has demonstrated significant antiviral activity in both in vitro and in vivo models against influenza virus strains (H3N2, H5N1) and herpes simplex viruses (types 1 and 2). Its most pronounced effect is seen when used preventively, where it can completely suppress viral replication and increase survival rates in animal models[8].

Minimal fragments of Selank, such as Gly-Pro, also retain antiviral activity, suggesting that specific peptide sequences are responsible for these effects[9].

Selank and its fragments induce significant changes in the expression of genes related to chemokines, cytokines, and their receptors in immune tissues. This modulation occurs within hours and may underlie its immunomodulatory and antiviral actions[9].

References

Vyunova, T., Andreeva, L., Shevchenko, K., & Myasoedov, N. (2018). Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.. Protein and peptide letters, 25 10, 914-923 . https://doi.org/10.2174/0929866525666180925144642.
V’yunova, T., Andreeva, L., Shevchenko, K., Shevchenko, V., & Myasoedov, N. (2014). Peptide regulation of specific ligand-receptor interactions of GABA with the plasma membranes of nerve cells. Neurochemical Journal, 8, 259 – 264. https://doi.org/10.1134/S1819712414040114.
Volkova, A., Shadrina, M., Kolomin, T., Andreeva, L., Limborska, S., Myasoedov, N., & Slominsky, P. (2016). Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Frontiers in Pharmacology, 7. https://doi.org/10.3389/fphar.2016.00031.
Filatova, E., Kasian, A., Kolomin, T., Rybalkina, E., Alieva, A., Andreeva, L., Limborska, S., Myasoedov, N., Pavlova, G., Slominsky, P., & Shadrina, M. (2017). GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells. Frontiers in Pharmacology, 8. https://doi.org/10.3389/fphar.2017.00089.
Medvedev, V., Tereshchenko, O., Israelian, A., Chobanu, I., Kost, N., Sokolov, O., & Miasoedov, N. (2014). [A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders].. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 114 7, 17-22 .
Kasian, A., Kolomin, T., Andreeva, L., Bondarenko, E., Myasoedov, N., Slominsky, P., & Shadrina, M. (2017). Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology, 2017. https://doi.org/10.1155/2017/5091027.
Kolik, L., Nadorova, A., Antipova, T., Kruglov, S., Kudrin, V., & Durnev, A. (2019). Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats. Bulletin of Experimental Biology and Medicine, 167, 641 – 644. https://doi.org/10.1007/s10517-019-04588-9.
Fi, E., Uchakin, P., Uchakina, O., Mezentseva, M., La, A., & Nf, M. (2009). [Antiviral activity of immunomodulator Selank in experimental influenza infection].. Voprosy virusologii, 54 5, 19-24.
Kolomin, T., Mikhalskaia, P., & Sedelnikova, A. (2023). Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments. Journal of Clinical Physiology and Pathology. https://doi.org/10.59315/jiscpp.2023-2-2.16-18.

COA

Certificate of Analysis for N-Acetyl-Selank

N-acetyl selank 98.5%

N-acetyl selank

Endotoxin Gel Clot Assay Report_N-Acetyl Selank_20mg_118261US_2-19-25_Limitless

Additional information

option	20mg , 30mg
lyophilized	lyophilized – 99%+ , lyophilized – 98.5%+ , non-lyophilized – 98.5%+

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