Name: AOD 9604 5mg
SKU: 15888
Availability: InStock

Description

AOD 9604 Product Description

This research-grade AOD9604 peptide provides laboratories with a reliable tool for investigating lipid metabolism and cellular energy pathways. Derived from the lipolytic region of human growth hormone, the 16 amino acids sequence retains key structural elements for focused research applications.

Our USA manufacturing process employs stringent quality controls and Good Manufacturing Practices to ensure consistent batch-to-batch performance. Independent laboratory verification confirms molecular integrity and purity standards required for publication-quality research. Intended for in vitro research applications only.

Peptide Specifications

SPECIFICATION	DESCRIPTION
Sequence	Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
Molecular Formula	C₇₈H₁₂₃N₂₃O₂₃S₂
Molecular Weight	1815.12 g/mol
CAS Number	221231-10-3
PubChem CID	71300630
Synonyms	AOD-9604, Tyr-hGH Fragment 176-191, HGH Fragment 177-191, Lipotropin
Purity	≥99% (HPLC)
Solubility	Soluble in bacteriostatic water
Storage Conditions	Store at ≤4°C, tightly sealed, away from heat and moisture
Physical Appearance	White lyophilized powder
Shelf Life	36 months from date of manufacture when stored properly
Quality Verification	Third-party tested by certified laboratory
Manufacturing Standard	USA-made, research-grade, GMP compliant
Intended Application	In vitro research applications only

Our Product Quality Guarantee

Every Limitless Biotech compound undergoes independent testing for endotoxins and sterility, meeting rigorous research standards through our systematic quality protocols and proactive manufacturing processes.

Buy AOD 9604 From Limitless Biotech

Limitless Biotech provides USA-manufactured peptide AOD9604 with verified molecular sequences and purity through comprehensive third-party testing. We ensure research quality with same-day shipping and dedicated customer support for your scientific endeavors.

Lyophilized Peptides: These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.

Non-Lyophilized Peptides: Offered as a dry powder, these peptides, while not as extensively processed as lyophilized peptides, still maintain a high level of purity. Their stability, though not as enhanced as in lyophilized form, is sufficient for maintaining quality under proper storage conditions.

Understanding Our Product Grades

We offer three distinct product grades to support varying research needs. Our Premium Lyophilized line is triple-tested for purity, endotoxins, and sterility, and in most cases includes both double third-party testing and manufacturer HPLC verification. The Standard Lyophilized grade is third-party purity tested and manufacturer verified. Our Standard (Non-Lyophilized) products are also manufacturer verified and third-party purity tested. All products meet a minimum purity of 98.5%, with the vast majority exceeding 99%. Each designation reflects a specific level of quality control and preparation.

Legal Disclaimer

This product is sold as a pure compound for research purposes only and is not meant for use as a dietary supplement. Please refer to our terms and conditions prior to purchase.

Safety Information: Keep this product out of the reach of children. This material has limited research available about it and may result in adverse effects if improperly handled or consumed. This product is not a dietary supplement, but a pure substance, sold as a raw material. We attest exclusively to the quality, purity and description of the materials we provide. This product is for use and handling only by persons with the knowledge and equipment to safely handle this material. You agree to indemnify us for any adverse effects that may arise from improper handling and/or consumption of this product.

The articles and information on products that may be found on this website are provided exclusively for the purposes of providing information and education. These items are not pharmaceuticals or medications, and the Food and Drug Administration has not given permission for the treatment or prevention of any disease, medical condition, or ailment using them.

Research

AOD9604 is a synthetic peptide fragment of human growth hormone (hGH) developed for its fat-reducing properties without the adverse metabolic effects of full-length hGH. Research on AOD9604 spans its mechanisms of action, metabolic effects, and broader applications.

Mechanisms of Action of AOD9604

AOD9604 mimics the lipolytic (fat burning) activity of hGH but does not interact with the hGH receptor or stimulate cell proliferation, distinguishing its mechanism from that of the parent hormone. Studies in obese mice show that AOD9604 increases fat oxidation and plasma glycerol (a marker of lipolysis) without affecting glucose metabolism or insulin secretion^[1].

This suggests that AOD9604 acts through pathways independent of the hGH receptor, possibly by upregulating β3-adrenergic receptor expression in adipose tissue, which enhances lipolytic sensitivity. However, its effects are not directly mediated by β3-adrenergic receptors, as shown by experiments in β3-AR knockout mice, where acute but not chronic effects on fat metabolism were observed^[2].

Metabolic and Anti-Obesity Effects

Animal studies consistently demonstrate that AOD9604 reduces body weight gain and increases fat oxidation in obese rodents. Chronic administration leads to significant reductions in adiposity and improved metabolic profiles, with no observed negative impact on insulin sensitivity or glucose tolerance^[1].

These findings support the potential of AOD9604 as a safe anti-obesity agent, distinct from hGH, which can cause hyperglycemia and insulin resistance^[3].

Osteoarthritis (OA) Models

In a rabbit OA model, injections of AOD9604, HA, or their combination were compared to saline. All groups showed less cartilage degeneration than saline alone^[4].

The combination of AOD9604 and HA resulted in the best outcomes, with significantly lower cartilage damage and a shorter period of lameness compared to either alone or saline^[4].

NALFD Models

Studies in mice with nonalcoholic fatty liver disease (NAFLD) suggest that AOD9604, particularly when combined with endurance exercise, may help improve liver enzyme profiles and insulin resistance, though exercise alone showed the most pronounced benefits^[5].

References

Heffernan, M., Thorburn, A., Fam, B., Summers, R., Conway-Campbell, B., Waters, M., & Ng, F. (2001). Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. International Journal of Obesity, 25, 1442-1449. https://doi.org/10.1038/sj.ijo.0801740.
Heffernan, M., Summers, R., Thorburn, A., Ogru, E., Gianello, R., Jiang, W., & Ng, F. (2001). The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.. Endocrinology, 142 12, 5182-9 . https://doi.org/10.1210/en.142.12.5182.
Ng, F., Sun, J., Sharma, L., Libinaka, R., Jiang, W., & Gianello, R. (2001). Metabolic Studies of a Synthetic Lipolytic Domain (AOD9604) of Human Growth Hormone. Hormone Research in Paediatrics, 53, 274 – 278. https://doi.org/10.1159/000053183.
Kwon, D., & Park, G. (2015). Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model.. Annals of clinical and laboratory science, 45 4, 426-32 .
Dehbashi, M., Fathi, M., Hosseini, S., & Mosaferi, M. (2021). The Effect of Eight Weeks Endurance Training, Somatropin Injection, and Its Lipolytic Fragment (AOD9604) on Cytokeratin-18 and Liver Enzymes of Mice Induced Liver Damage Due to a High-Fat Diet. Quarterly of Horizon of Medical Sciences. https://doi.org/10.32598/hms.27.4.3513.1.

COA

Report 99%+ grade

Certificate of Analysis for AOD-9604

AOD

AOD hplc AOD MS

Additional information

Option	lyophilized – 99%+ , lyophilized – 98.5%+

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