9-Me-BC Powder, 500mg / 1 Gram

9-Me-BC is a synthetic β-carboline alkaloid that has been extensively studied for its effects on dopaminergic neurons and related brain systems. Research demonstrates multiple mechanisms through which this compound influences neuronal development, mitochondrial function, and cellular signaling pathways.

Dopaminergic Neuron Development

9-Me-BC increases the number of tyrosine hydroxylase-positive neurons by converting pre-existing neurons into functional dopaminergic cells[1]. This conversion involves upregulation of transcription factors including GATA2, GATA3, CREB, and CREBBP[2].

The compound enhances tyrosine hydroxylase protein expression by approximately 75% per cell while promoting neurite outgrowth[3]. Uptake occurs through the dopamine transporter with maximum kinetics achieved after three hours[1].

Neurotrophic Factor Production

Studies show 9-Me-BC increases artemin expression by 3.2-fold in astrocyte cultures, along with elevated BDNF and neurotrophin-3 levels. The compound also enhances NCAM1 and TGF-β2 expression, both important for neurite outgrowth[1].

These neurotrophic factors work together to support neuron survival and morphological differentiation. The effects appear mediated through astrocytes, which produce and release protective factors in response to 9-Me-BC[1].

Mitochondrial Function

Research using MPTP-induced models shows 9-Me-BC increases Complex I activity by approximately 80%[4]. This enhancement of respiratory chain function addresses core mitochondrial impairment mechanisms.

Complex I dysfunction occurs in various neurodegenerative conditions. The compound’s ability to restore mitochondrial respiratory capacity represents a fundamental protective mechanism.

Monoamine Oxidase Activity

9-Me-BC functions as a dual MAO inhibitor with IC50 values of 1 μM for MAO-A and 15.5 μM for MAO-B. This inhibitory profile helps preserve dopamine levels while reducing toxic metabolite formation[1].

The enzyme inhibition also prevents conversion of neurotoxic precursors like MPTP into their active forms. Dual inhibition reduces harmful byproducts including hydrogen peroxide and aldehydes[1].

Anti-inflammatory Effects

The compound inhibits microglial proliferation and reduces inflammatory cytokines within the nervous system. Studies show protection against lipopolysaccharide-induced inflammation and other neurotoxic insults[2].

9-Me-BC also reduces alpha-synuclein protein levels in research models. Treatment after rotenone-induced damage resulted in pronounced neuron regeneration[2].

9-Me-BC is a synthetic β-carboline alkaloid that has been extensively studied for its effects on dopaminergic neurons and related brain systems. Research demonstrates multiple mechanisms through which this compound influences neuronal development, mitochondrial function, and cellular signaling pathways.

References

1. S. Keller, W. H. Polanski, C. Enzensperger, H. Reichmann, A. Hermann, and G. Gille, “9-Methyl-β-carboline inhibits monoamine oxidase activity and stimulates the expression of neurotrophic factors by astrocytes,” Springer Science and Business Media LLC, Apr. 2020. doi: 10.1007/s00702-020-02189-9. Available: https://doi.org/10.1007/s00702-020-02189-9
2. W. Polanski, C. Enzensperger, H. Reichmann, and G. Gille, “The exceptional properties of 9‐methyl‐β‐carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti‐inflammatory effects,” Wiley, Jun. 2010. doi: 10.1111/j.1471-4159.2010.06725.x. Available: https://doi.org/10.1111/j.1471-4159.2010.06725.x
3. W. Polanski, H. Reichmann, and G. Gille, “Stimulation, protection and regeneration of dopaminergic neurons by 9-methyl-β-carboline: a new anti-Parkinson drug?,” Informa UK Limited, Jun. 2011. doi: 10.1586/ern.11.1. Available: https://doi.org/10.1586/ern.11.1
4. C. Wernicke et al., “9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson’s disease.,” Pharmacological Reports, vol. 62 1, pp. 35–53, 2010.